Abnormal Gastrointestinal Flora in Late-Onset Autism

Finegold SM et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002 35(Suppl 1):S6-S16 PMID 12173102

“Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non-spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.”

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Should anyone with autism be considered for gastric bypass surgery?

New Autism Epidemiology Study

Download this autism epidemiology study (in PDF format)
http://download.journals.elsevierhealth.com/pdfs/journals/0033-3549/PIIS0033354904001347.pdf

Synopsis: Increases in the reported prevalence of autism and autistic spectrum disorders in recent years have fueled concern over possible environmental causes. The author reviews the available survey literature and finds evidence of large increases in prevalence in both the United States and the United Kingdom that cannot be explained by changes in diagnostic criteria or improvements in case ascertainment. Incomplete ascertainment of autism cases in young child populations is the largest source of predictable bias in prevalence surveys; however, this bias has, if anything, worked against the detection of an upward trend in recent surveys. Comparison of autism rates by year of birth for specific geographies provides the strongest basis for trend assessment. Such comparisons show large recent increases in rates of autism and autistic spectrum disorders in both the U.S. and the U.K. Reported rates of autism in the United States increased from ,3 per 10,000 children in the 1970s to .30 per 10,000 children in the 1990s, a 10-fold increase. In the United Kingdom, autism rates rose from ,10 per 10,000 in the 1980s to roughly 30 per 10,000 in the 1990s. Reported rates for the full spectrum of autistic disorders rose from the 5 to 10 per 10,000 range to the 50 to 80 per 10,000 range in the two countries. A precautionary approach suggests that the rising incidence of autism should be a matter of urgent public concern.

Clinical Analysis of Glutathione

Pastore A et al. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 2003 Jul 1;333(1):19-39. PMID: 12809732

“Glutathione...plays a central role in cell biology. It is implicated in the cellular defence against xenobiotics and naturally occurring deleterious compounds, such as free radicals and hydroperoxides… Glutathione is a critical factor in protecting organisms against toxicity and disease."

Glutathione Identified As Possible Autism Cure

Glutathione has been identified as a potential remedy for several disorders, one of which is autism.

Glutathione (GSH) is a tripeptide. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione, an antioxidant, protects cells from toxins such as free radicals.

Simply put, glutathione (GSH) is the body’s master antioxidant. It is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging. Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine. In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.

Modern research has shown that individuals who have low levels of glutathione are susceptible to chronic illness. Decreased levels of glutathione can be brought about by continual stress upon the immune system. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle. Autism is an example of a condition that is always associated with a lowered immune system. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione.

Glutathione has been shown to slow down the aging process, detoxify and improve liver function, strengthen the immune system, and reduce the chances of developing cancer. It is now also seen as a potential remedy for Autism, since glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.

Glutathione may not be well-known outside of medical circles, but your body relies on its function every single day.

Important Roles of Glutathione

• Fights against oxidative cell damage (from free radicals)

• Protein Synthesis

• Amino Acid transport

• Cellular detoxification

• Immune system enhancement

• Enzyme activation

• Fights cellular Inflammation

• ATP (energy) production

Our cells are constantly under attack by free radicals, which can cause a reduction of our cells' ability to function optimally. Autism could in fact be caused - at least in some cases - by free radicals.

Where do free radicals come from?

• Created during normal metabolism

• Environmental pollutants like radiation, herbicides, pesticides

• Cigarette smoke

Types of Free Radicals

The fight against free radicals is often a tricky one. There is not a singular form of free radical. Science has confirmed that there are many different types of free radicals, including:

• Superoxide

• Hydrogen Peroxide

• Singlet Oxygen and Hydroxyl Radicals

Important Note: Not all antioxidants can sufficiently match up with all types of free radicals. The great news about glutathione is that regardless of the type of free radical, glutathione has the ability to properly match up and neutralize it, thus increasing cellular protection and function. This is great news for those searching for a cure for Autism.

Autism Miracles

Autism miracles sometimes do happen. This is an effort to document them and help others to find answers for themselves.

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